Mesenchymal Stem Cells - Interest Group
This website serves as a single key resource for up-to-date
information on mesenchymal stem cell research. It provides links
to current papers, protocols, and information about providers of
MSC research products. It also includes a forum for
mesenchymal stem cell (MSC) researchers to facilitate
communication. It is a place to post questions and receive
community answers.
Mesenchymal stem cells, or MSCs, are multipotent stem cells
that can differentiate into a variety of cell types. Cell types that
MSCs have been shown to differentiate into in vitro or in vivo
include osteoblasts, chondrocytes, myocytes, adipocytes, and,
as described lately, beta-pancreatic islets cells.
MSCs are rare in bone marrow, representing ~1 in 10,000
nucleated cells. Although not immortal, they have the ability to
expand manyfold in culture while retaining their growth and
multilineage potential. MSCs are identified by the expression of
many molecules including CD105 (SH2) and CD73 (SH3/4) and
are negative for the hematopoietic markers CD34, CD45, and
CD14.
The properties of MSCs make these cells potentially ideal
candidates for tissue engineering. It has been shown that
MSCs, when transplanted systemically, are able to migrate to
sites of injury in animals, suggesting that MSCs possess
migratory capacity. However, the mechanisms underlying the
migration of these cells remain unclear. Chemokine receptors
and their ligands and adhesion molecules play an important role
in tissue-specific homing of leukocytes and have also been
implicated in trafficking of hematopoietic precursors into and
through tissue. Several studies have reported the functional
expression of various chemokine receptors and adhesion
molecules on human MSCs. Harnessing the migratory potential
of MSCs by modulating their chemokine-chemokine receptor
interactions may be a powerful way to increase their ability to
correct inherited disorders of mesenchymal tissues or facilitate
tissue repair in vivo.
Mesenchymal stem cells are characterized morphologically by a
small cell body with a few cell processes that are long and thin.
The cell body contains a large, round nucleus with a prominent
nucleolus which is surrounded by finely dispersed chromatin
particles, giving the nucleus a clear appearance. The remainder
of the cell body contains a small amount of Golgi apparatus,
rough endoplasmic reticulum, mitochondria, and polyribosomes.
The cells, which are long and thin, are widely dispersed and the
adjacent extracellular matrix is populated by a few reticular
fibrils but is devoid of the other types of collagen fibrils.
information on mesenchymal stem cell research. It provides links
to current papers, protocols, and information about providers of
MSC research products. It also includes a forum for
mesenchymal stem cell (MSC) researchers to facilitate
communication. It is a place to post questions and receive
community answers.
Mesenchymal stem cells, or MSCs, are multipotent stem cells
that can differentiate into a variety of cell types. Cell types that
MSCs have been shown to differentiate into in vitro or in vivo
include osteoblasts, chondrocytes, myocytes, adipocytes, and,
as described lately, beta-pancreatic islets cells.
MSCs are rare in bone marrow, representing ~1 in 10,000
nucleated cells. Although not immortal, they have the ability to
expand manyfold in culture while retaining their growth and
multilineage potential. MSCs are identified by the expression of
many molecules including CD105 (SH2) and CD73 (SH3/4) and
are negative for the hematopoietic markers CD34, CD45, and
CD14.
The properties of MSCs make these cells potentially ideal
candidates for tissue engineering. It has been shown that
MSCs, when transplanted systemically, are able to migrate to
sites of injury in animals, suggesting that MSCs possess
migratory capacity. However, the mechanisms underlying the
migration of these cells remain unclear. Chemokine receptors
and their ligands and adhesion molecules play an important role
in tissue-specific homing of leukocytes and have also been
implicated in trafficking of hematopoietic precursors into and
through tissue. Several studies have reported the functional
expression of various chemokine receptors and adhesion
molecules on human MSCs. Harnessing the migratory potential
of MSCs by modulating their chemokine-chemokine receptor
interactions may be a powerful way to increase their ability to
correct inherited disorders of mesenchymal tissues or facilitate
tissue repair in vivo.
Mesenchymal stem cells are characterized morphologically by a
small cell body with a few cell processes that are long and thin.
The cell body contains a large, round nucleus with a prominent
nucleolus which is surrounded by finely dispersed chromatin
particles, giving the nucleus a clear appearance. The remainder
of the cell body contains a small amount of Golgi apparatus,
rough endoplasmic reticulum, mitochondria, and polyribosomes.
The cells, which are long and thin, are widely dispersed and the
adjacent extracellular matrix is populated by a few reticular
fibrils but is devoid of the other types of collagen fibrils.
| MSCs can contribute to the regeneration of mesenchymal derivatives, including bone, cartilage, muscle, ligament, tendon, and adipose. |
| Mesenchymal Stem Cells - Advances & Applications (Aug 2011) BioInformant Worldwide LLC *Featured Report* |
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